Bioengineering stents

Bioengineering stents are also called antibody-coated stents.

This type of stent is different from drug-coated stents (DCS) because it does not contain a polymer or drug.

Antibodies from the stent’s surface attract endothelial progenitor cells (EPC) that come from human bone marrow.

As a result, it helps speed up the lining of the arteries with cells (endothelialization), promoting natural healing.

It provides rapid coverage of the stent surface with a reduced risk of early and late thrombosis (blood clots).

Detailed example of bioengineering stent

A bioengineering stent is a stainless steel coronary artery stent coated with a biocompatible matrix with applied CD34-specific antibodies, surface antigens present on circulating endothelial progenitor cells (EPC).

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After stent implantation, these antibodies capture endogenous EPCs from the circulating blood flow, which then mature to endothelial cells.

The described process results in a fast and controlled endothelial treatment, thereby simplifying and speeding up the natural treatment process while minimizing the time during which the stent surface poses the risk of thrombosis.

As a result of this rapid endothelialization, the manufacturer recommends a duration of double antiplatelet therapy of only 4 weeks.

This has a potential advantage over traditional stenting of patients with pure metal stents requiring non-cardiac surgery, taking into account the required period of antiplatelet therapy.

These stents can be very useful for patients requiring urgent non-cardiac surgery.

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